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Bisoprolol dose adjustment based on age alone is not necessary. Diltiazem may increase the hypotensive activities of Bufuralol. The risk or severity of adverse effects can be increased when Clonidine is combined with Flunarizine. Patients tend to prefer selective serotonin reuptake inhibitors (SSRIs) and only move to tricyclic antidepressants when SSRIs fail [ R]. Valproic acid is listed in Pregnancy Category D. Where Pseudomonas aeruginosa is a documented or presumptive pathogen, combination therapy with an anti-pseudomonal β-lactam is recommended [ see Clinical Studies (14.
